Relevance of anti-BmR1 IgG4 antibodies in children from an area endemic for Brugia malayi infection in Kerala, India.
Identifieur interne : 006057 ( Main/Exploration ); précédent : 006056; suivant : 006058Relevance of anti-BmR1 IgG4 antibodies in children from an area endemic for Brugia malayi infection in Kerala, India.
Auteurs : R K Shenoy [Inde] ; N. Rahmah ; T K Suma ; V. Kumaraswami ; A X Thaslim ; R B GopuSource :
- The Journal of communicable diseases [ 0019-5138 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Animaux, Anticorps antihelminthe (immunologie), Anticorps antihelminthe (sang), Brugia malayi (immunologie), Brugia malayi (isolement et purification), Dépistage systématique (), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (), Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Immunoglobuline G (immunologie), Immunoglobuline G (sang), Inde (épidémiologie), Maladies endémiques (), Mâle, Trousses de réactifs pour diagnostic.
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Anticorps antihelminthe, Brugia malayi, Filariose lymphatique, Immunoglobuline G.
- isolement et purification : Brugia malayi.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- épidémiologie : Filariose lymphatique, Inde.
- Adolescent, Animaux, Dépistage systématique, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Maladies endémiques, Mâle, Trousses de réactifs pour diagnostic.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adolescent, Animals, Antibodies, Helminth (blood), Antibodies, Helminth (immunology), Brugia malayi (immunology), Brugia malayi (isolation & purification), Child, Child, Preschool, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (prevention & control), Endemic Diseases (prevention & control), Female, Humans, Immunoglobulin G (blood), Immunoglobulin G (immunology), India (epidemiology), Male, Mass Screening (methods), Reagent Kits, Diagnostic.
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , immunology : Antibodies, Helminth, Immunoglobulin G.
- geographic , epidemiology : India.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Brugia malayi, Elephantiasis, Filarial.
- isolation & purification : Brugia malayi.
- methods : Mass Screening.
- prevention & control : Elephantiasis, Filarial, Endemic Diseases.
- Adolescent, Animals, Child, Child, Preschool, Female, Humans, Male, Reagent Kits, Diagnostic.
Abstract
Brugian filariasis prevalent mostly in South-East Asian countries including India contributes to a small but significant proportion of the socioeconomic burden due to lymphatic filariasis. Along with bancroftian filariasis, brugian filariasis has been targeted for elimination globally. The lack of a reliable daytime diagnostic test has been seen as an important barrier to the successful implementation and monitoring of elimination programmes in brugia endemic areas. We evaluated an anti-BmRI-IgG4 antibody test namely, 'Brugia Rapid' in a large study meant to understand the clinical and pathological manifestations of brugian filariasis in children. We found the test superior to traditional night blood screening for microfilaraemia. Although an antibody detection test, we found it to be a reliable indicator of brugian infection. Among the 100 children studied extensively, 94% of the microfilaraemics, 86% of those showing filarial dance sign indicating presence of, live adult worms and 78% having abnormal lymphatics on lymphoscintigraphy were IgG4 positive. Coupled with its advantages like ease of use any time of the day, high sensitivity and specificity, this test may be the ideal tool to assist programme managers in their efforts to eliminate lymphatic filariasis where brugian infections are found.
PubMed: 22010493
Affiliations:
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Le document en format XML
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<term>Brugia malayi (immunology)</term>
<term>Brugia malayi (isolation & purification)</term>
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<term>Mass Screening (methods)</term>
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<front><div type="abstract" xml:lang="en">Brugian filariasis prevalent mostly in South-East Asian countries including India contributes to a small but significant proportion of the socioeconomic burden due to lymphatic filariasis. Along with bancroftian filariasis, brugian filariasis has been targeted for elimination globally. The lack of a reliable daytime diagnostic test has been seen as an important barrier to the successful implementation and monitoring of elimination programmes in brugia endemic areas. We evaluated an anti-BmRI-IgG4 antibody test namely, 'Brugia Rapid' in a large study meant to understand the clinical and pathological manifestations of brugian filariasis in children. We found the test superior to traditional night blood screening for microfilaraemia. Although an antibody detection test, we found it to be a reliable indicator of brugian infection. Among the 100 children studied extensively, 94% of the microfilaraemics, 86% of those showing filarial dance sign indicating presence of, live adult worms and 78% having abnormal lymphatics on lymphoscintigraphy were IgG4 positive. Coupled with its advantages like ease of use any time of the day, high sensitivity and specificity, this test may be the ideal tool to assist programme managers in their efforts to eliminate lymphatic filariasis where brugian infections are found.</div>
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